Topiramate (Generic Topamax) is used with other drugs to control various types of convulsions and seizures of epilepsy.

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10 Tab(s) 25mg Topiramate $4.00 30 Tab(s) 25mg Topiramate $12.00 60 Tab(s) 25mg Topiramate $24.00 90 Tab(s) 25mg Topiramate $34.00 120 Tab(s) 25mg Topiramate $46.00 180 Tab(s) 25mg Topiramate $66.00

GENERIC NAME: Topiramate
BRAND NAME: Topamax

Why is Topiramate prescribed?
Topiramate is used alone or with other medications to treat certain types of seizures in people who have epilepsy. Topiramate is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topiramate is used to treat patients who continue to have seizures even when they take other anti-seizure medications. Topiramate is also used to prevent migraine headaches, but not to relieve the pain of migraine headaches when they occur. Topiramate is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

How should Topiramate be used?
Topiramate comes as a tablet and a sprinkle capsule (capsule that contains small beads of medication that can be sprinkled on food) to take by mouth. It is usually taken with or without food twice a day in the morning and evening. Take Topiramate at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Topiramate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

There is another medication with a name similar to the brand name for Topiramate. You should be sure that you receive Topiramate and not the similar medication each time you fill your prescription. Be sure that the prescription your doctor gives you is clear and easy to read. Talk to your pharmacist to be sure that you are given Topiramate. After you receive your medication, compare the tablets to the pictures in the manufacturer's patient information sheet. If you think you were given the wrong medication, talk to your pharmacist. Do not take any medication unless you are certain it is the medication that your doctor prescribed.

Topiramate tablets have a bitter taste and lose their effectiveness quickly when broken, so you should swallow them whole. Do not split, chew, or crush them.

Your doctor will probably start you on a low dose of Topiramate and gradually increase your dose, not more than once every week.

Topiramate may control your seizures or migraines, but will not cure your condition. Continue to take Topiramate even if you feel well. Do not stop taking Topiramate without talking to your doctor. If you suddenly stop taking Topiramate, you may have severe seizures, even if you have not had seizures in the past. Your doctor will probably decrease your dose gradually.

The sprinkle capsules may be swallowed whole or opened and poured over food. To take the sprinkle capsule with food, follow these steps:

Prepare a teaspoonful of soft food such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt.
Hold the capsule upright over the food. You should be able to read the word 'TOP' on the capsule.
Twist off the clear part of the capsule and pour the entire contents onto the spoonful of food.
Swallow the entire mixture immediately without chewing.
Drink fluids right after swallowing to wash down the mixture and to be sure that you swallow all of it.

Other uses for Topiramate
Topiramate is also used for the management of alcohol dependence. Talk to your doctor about the risks of using Topiramate for your condition.

What special precautions should I follow?
Before taking Topiramate,

tell your doctor and pharmacist if you are allergic to Topiramate or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: acetazolamide (Diamox); amitriptyline; antidepressants; antihistamines; dichlorphenamide (Daranide); digoxin (Lanoxin, Digitek); ipratropium (Atrovent); iron; isoniazid (INH, Nydrazid); hydrochlorothiazide (Microzide, Oretic); lithium (Eskalith, Lithobid); medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, ulcers, or urinary problems; metformin (Glucophage); methazolamide; oral contraceptives (birth control pills); other medications for seizures such as carbamazepine (Tegretol) and phenytoin (Dilantin, Phenytek); pioglitazone (Actos); risperidone (Risperdal); salicylate pain relievers such as aspirin, choline magnesium trisalicylate (Trisalate), choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, others), and salsalate (Argesic, Disalcid, Salgesic); sedatives; sleeping pills; tranquilizers; valproic acid (Depakene, Depakote); and zonisamide (Zonegran). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you or any family members have or have ever had kidney stones, if you drink or have ever drunk large amounts of alcohol, and if you have ever thought about killing yourself or tried to do so. Also tell you doctor if you have or have ever had metabolic acidosis (a disturbance in the body's acid-base balance that results in excessive acidity of the blood.); osteopenia, osteomalacia, or osteoporosis (conditions in which the bones are soft or brittle and may break easily); diabetes; glaucoma (a type of eye disease); any disease that affects your breathing such as asthma or chronic obstructive pulmonary disease (COPD); depression or abnormal moods; a growth problem; or liver or kidney disease. Also tell your doctor if you have diarrhea or if you develop diarrhea during your treatment.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Topiramate, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Topiramate.
you should know that Topiramate may make you drowsy, dizzy, confused, or unable to concentrate. Do not drive a car or operate machinery until you know how Topiramate affects you.
if you are taking Topiramate to control seizures, you should know that you may continue to have seizures during your treatment. You may need to avoid activities such as swimming, driving, and climbing so that you will not harm yourself or others if you lose consciousness during a seizure.
ask your doctor about the safe use of alcoholic beverages while you are taking Topiramate.
if you are taking oral contraceptives (birth control pills), tell your doctor if unexpected bleeding or spotting occurs. Topiramate can decrease the effectiveness of oral contraceptives.
you should know that Topiramate can prevent you from sweating and make it harder for your body to cool down when it gets very hot. This happens most often in warm weather and to children who take Topiramate. Avoid exposure to heat, drink plenty of fluids and tell your doctor if you have a fever, headache, muscle cramps, or an upset stomach, or if you are not sweating as usual.
you should know that you may be more likely to develop a kidney stone while you are taking Topiramate. Drink 6-8 glasses of water every day to prevent kidney stones from forming.
you should know that your mental health may change in unexpected ways, and you may become suicidal (thinking about harming or killing yourself or planning or trying to do so) while you are taking Topiramate for the treatment of epilepsy, mental illness, or other conditions. A small number of adults and children 5 years of age and older who took antiepileptics such as Topiramate during clinical studies were found to be twice as likely to become suicidal than people who did not take the medication. This increased risk of suicidal behavior was seen as early as one week after starting the medication. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: anxiety, agitation, hostility, mania (frenzied, abnormally excited mood), talking or thinking about wanting to hurt yourself or end your life, withdrawing from friends and family, new or worsening depression, preoccupation with death and dying, or giving away prized possessions. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
What special dietary instructions should I follow?
Talk to your doctor about increasing the amount of food you eat if you lose weight while you are taking Topiramate.

Talk to your doctor before changing your diet or beginning any type of weight loss program. Do not follow a ketogenic diet (a high-fat, low-carbohydrate diet used to control seizures) or any other high-fat, low-carbohydrate diet, such as the Atkins diet, while you are taking Topiramate.

What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is less than 6 hours before you are scheduled to take your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can Topiramate cause?
Topiramate may cause other side effects. Tell your doctor if any of these symptoms are severe or do not go away:

numbness, burning, or tingling in the hands or feet
slowed reactions
difficulty concentrating
speech problems, especially difficulty thinking of specific words
memory problems
lack of coordination
confusion
nervousness
aggressive behavior
irritability
mood swings
depression
headache
drowsiness
weakness
excessive movement
uncontrollable shaking of a part of the body
uncontrollable eye movements
extreme thirst
weight loss
constipation
diarrhea
gas
heartburn
change in ability to taste food
swelling of the tongue
overgrowth of the gums
dry mouth
increased saliva
trouble swallowing
nosebleed
teary or dry eyes
back, muscle, or bone pain
missed menstrual periods
excessive menstrual bleeding
skin problems or changes in skin color
dandruff
hair loss
growth of hair in unusual places
ringing in the ears
difficulty falling or staying asleep
swelling of the hands, arms, feet, ankles, or lower legs
difficulty urinating or pain when urinating

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

blurred vision
double vision
eye pain
worsening of seizures
slow heart rate
pounding or irregular heartbeat
chest pain
trouble breathing
fast, shallow breathing
inability to respond to things around you
excessive tiredness
nausea
vomiting
stomach pain
loss of appetite
intense back or side pain
bloody, cloudy, or foul smelling urine
constant need to urinate
fever
chills

Topiramate may cause osteoporosis (a condition in which bones can break more easily) in adults and rickets (abnormal, curved bone growth) in children. Topiramate may also slow the growth of children and may decrease the final height that children reach. Talk to your doctor about the risks of taking Topiramate.

Topiramate may cause other side effects. Call your doctor if you have any unusual problems while taking Topiramate.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for Topiramate?
Keep Topiramate in the container it came in, tightly closed, and out of reach of children. Tablets should be stored at room temperature and away from excess heat and moisture (not in the bathroom). Sprinkle capsules should be stored at or below 77 °F, 25 °C. Never store broken tablets or mixtures of sprinkles and soft food. These should be used right away or thrown away. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

seizures
drowsiness
speech problems
blurred vision
double vision
trouble thinking
tiredness
loss of coordination
loss of consciousness
dizziness
stomach pain
vomiting
agitation
depression
loss of appetite
pounding or irregular heartbeat
fast, shallow breathing

What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to Topiramate.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.